Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Pang-Hung Hsu
LAB HEAD: Pang-Hung Hsu
PROVIDER: PXD017046 | Pride | 2021-01-25
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
anti-CD3_IP-NPGPx_1.csv | Csv | |||
anti-CD3_IP-NPGPx_1.mgf | Mgf | |||
anti-CD3_IP-NPGPx_1.raw | Raw | |||
anti-CD3_IP-NPGPx_2.csv | Csv | |||
anti-CD3_IP-NPGPx_2.mgf | Mgf |
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Free radical biology & medicine 20210116
Emerging evidences implicate the contribution of ROS to T cell activation and signaling. The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we show that deficiency of non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx), a redox sensor, results in T cell hyperproliferation and elevat ...[more]