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Integrated multi-omic analysis of Mycobacterium tuberculosis isolates identifies ethionamide resistance-associated gene pair Rv3094c-Rv3095

ABSTRACT: Global control of the tuberculosis (TB) epidemic is seriously threatened by increasing prevalence of drug resistant (DR) M. tuberculosis (MTB) isolates. Many genome-wide studies have identified DR-associated SNPs and investigated their role in DR mechanisms. However, DR in ~30% of isolates has no clear genetic basis. DR mechanisms related to variation in gene/protein expression are known, but not well-studied.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mycobacterium Tuberculosis H37rv

SUBMITTER: Sun jinshuai

LAB HEAD: Kanglin Wan

PROVIDER: PXD017079 | Pride | 2023-03-10

REPOSITORIES: Pride

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			Action	DRS
	20181017_XuPing_TMT8_1.raw	Raw
	20181017_XuPing_TMT8_1_RE.raw	Raw
	20181017_XuPing_TMT8_2.raw	Raw
	20181017_XuPing_TMT8_3.raw	Raw
	20181017_XuPing_TMT8_4.raw	Raw

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Publications

Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.

Wan Li L Hu Peilei P Zhang Lili L Wang Zhao-Xi ZX Fleming Joy J Ni Bo B Luo Jianjun J Guan Cha-Xiang CX Bai Liqiong L Tan Yunhong Y Liu Haican H Li Na N Xiao Tongyang T Bai Hua H Zhang Yong-An YA Zhang Xian-En XE Wan Kanglin K Bi Lijun L Ouyang Songying S Zhang Hongtai H

Communications biology 20230207 1

Global control of the tuberculosis epidemic is threatened by increasing prevalence of drug resistant M. tuberculosis isolates. Many genome-wide studies focus on SNP-associated drug resistance mechanisms, but drug resistance in 5-30% of M. tuberculosis isolates (varying with antibiotic) appears unrelated to reported SNPs, and alternative drug resistance mechanisms involving variation in gene/protein expression are not well-studied. Here, using an omics approach, we identify 388 genes with lineage ...[more]

PMID: 36750726

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