Dataset Information

Human plasma LC-MSMS for predicting drug-response progonosis in depressed patients at 0, 1, 4 and 10 visiting weeks

ABSTRACT: Patients with major depressive disorder (MDD) have a high relapse rate and first prescribed selective serotonin reuptake inhibitors (SSRIs). The selection process of an antidepressant agent is primarily guided by trial and error. If patients do not benefit from the initial course of antidepressant medication for at least 4-6 weeks, additional therapeutic strategies are required to gain remission, including switching within and between classes of antidepressants. In order to discovery SSRI-related plasma protein markers, we designed a retrospective study. In this study, four longitudinal plasma samples were collected from 10 patients during the 10-week drug reaction period after being diagnosed with depression, and more than a thousand plasma proteins were identified by highly sensitive nanoflow liquid chromatography-tandem mass spectrometry (LC−MS/MS).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Kyunggon Kim

LAB HEAD: Kyunggon Kim

PROVIDER: PXD017211 | Pride | 2020-11-03

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	181011_Leaders_11_1_E01.raw	Raw
	181011_Leaders_11_1_E02.raw	Raw
	181011_Leaders_11_1_E04.raw	Raw
	181011_Leaders_11_2_E01.raw	Raw
	181011_Leaders_11_2_E02.raw	Raw

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Publications

An Exploratory Pilot Study with Plasma Protein Signatures Associated with Response of Patients with Depression to Antidepressant Treatment for 10 Weeks.

Kim Eun Young EY Ahn Hee-Sung HS Lee Min Young MY Yu Jiyoung J Yeom Jeonghun J Jeong Hwangkyo H Min Hophil H Lee Hyun Jeong HJ Kim Kyunggon K Ahn Yong Min YM

Biomedicines 20201028 11

Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent course. Recognition of biological markers that could predict and monitor response to drug treatment could personalize clinical decision-making, minimize unnecessary drug exposure, and achieve better outcomes. Four longitudinal plasma samples were collected from each of ten patients with MDD treated with antidepressants for 10 weeks. Plasma proteins were analyzed qualitatively and quantitatively w ...[more]

PMID: 33126421

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