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“phyloquant” to study the evolutionary relationships of organisms based on large scale quantitative protein expression

ABSTRACT: “phyloquant” to study the evolutionary relationships of organisms based on large scale quantitative protein expression

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Trypanosoma Rangeli Sc58 Trypanosoma Cruzi Marinkellei Trypanosoma Dionisii Trypanosoma Cruzi Trypanosoma Erneyi

TISSUE(S): Cell Culture

DISEASE(S): Chagas Disease

SUBMITTER: Livia Rosa-Fernandes

LAB HEAD: Giuseppe Palmisano

PROVIDER: PXD017228 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

PhyloQuant approach provides insights into Trypanosoma cruzi evolution using a systems-wide mass spectrometry-based quantitative protein profile.

Mule Simon Ngao SN Costa-Martins André Guilherme AG Rosa-Fernandes Livia L de Oliveira Gilberto Santos GS Rodrigues Carla Monadeli F CMF Quina Daniel D Rosein Graziella E GE Teixeira Marta Maria Geraldes MMG Palmisano Giuseppe G

Communications biology 20210311 1

The etiological agent of Chagas disease, Trypanosoma cruzi, is a complex of seven genetic subdivisions termed discrete typing units (DTUs), TcI-TcVI and Tcbat. The relevance of T. cruzi genetic diversity to the variable clinical course of the disease, virulence, pathogenicity, drug resistance, transmission cycles and ecological distribution requires understanding the parasite origin and population structure. In this study, we introduce the PhyloQuant approach to infer the evolutionary relationsh ...[more]

PMID: 33707618

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Evolutionary relationships among extradiol dioxygenases.

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Common Functions of Disordered Proteins across Evolutionary Distant Organisms.

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