Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: TuKiet Lam
LAB HEAD: TuKiet Lam
PROVIDER: PXD017270 | Pride | 2022-05-19
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 120 |
Gorenberg Erica L EL Massaro Tieze Sofia S Yücel Betül B Zhao Helen R HR Chou Vicky V Wirak Gregory S GS Tomita Susumu S Lam TuKiet T TT Chandra Sreeganga S SS
PLoS biology 20220331 3
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation on molecular dissection of disease mechanisms and therapeutic development. Here, we provide a resource identifying >100 novel PPT1 substrates. We utilized Acyl Resin-Assisted Capture (Acyl RAC) and mass spectrometry to identify proteins with increas ...[more]