Dataset Information

Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis

ABSTRACT: mass spectrometry analysis of aged and adult hematopoietic stem cells, multipotent progenitors and oligopotent progenitors

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Common Myeloid Progenitor, Common Lymphoid Progenitor, Hematopoietic Multipotent Progenitor Cell, Hematopoietic Stem Cell, Megakaryocyte-erythroid Progenitor Cell, Bone Marrow, Granulocyte Monocyte Progenitor Cell

DISEASE(S): Disease Free

SUBMITTER: Janos Demeter

LAB HEAD: Irving L. Weissman

PROVIDER: PXD017442 | Pride | 2021-07-24

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	180705_BZaro_Weismann_8497_HSC1_01_Slot1-19_01_1276.d.zip	Other
	180705_BZaro_Weismann_8497_HSC1_01_Slot1-19_01_1276.d_20200115_Byonic.mgf	Mgf
	180705_BZaro_Weismann_8497_HSC1_01_Slot1-19_01_1276.d_20200115_Byonic.mzid.gz	Mzid
	180705_BZaro_Weismann_8497_HSC1_01_Slot1-19_01_1276.d_20200115_Byonic.pride.mgf.gz	Mgf
	180705_BZaro_Weismann_8497_HSC1_01_Slot1-19_01_1276.d_20200115_Byonic.pride.mztab.gz	Mztab

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Publications

Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.

Zaro Balyn W BW Noh Joseph J JJ Mascetti Victoria L VL Demeter Janos J George Benson B Zukowska Monika M Gulati Gunsagar S GS Sinha Rahul R Flynn Ryan A RA Banuelos Allison A Zhang Allison A Wilkinson Adam C AC Jackson Peter P Weissman Irving L IL

eLife 20201125

The balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a healthy blood supply; imbalances underlie hematological diseases. The importance of HSCs and their progenitors have led to their extensive characterization at genomic and transcriptomic levels. However, the proteomics of hematopoiesis remains incompletely understood. Here we report a proteomics resource from mass spectrometry of mouse young adult and old adult mouse HSCs, multipotent progenitors and o ...[more]

PMID: 33236985

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