Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Brain Stem Glioma
SUBMITTER: Dupuy Jean-William
LAB HEAD: Martin Hagedorn
PROVIDER: PXD017525 | Pride | 2022-04-01
REPOSITORIES: Pride
Action | DRS | |||
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Linkbetweenfiles.xlsx | Xlsx | |||
RP_UP000005640_Homo_sapiens_190516.fasta | Fasta | |||
mh190729_01.msf | Msf | |||
mh190729_01.pdResult | Other | |||
mh190729_01.raw | Raw |
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Neuro-oncology advances 20220101 1
<h4>Background</h4>Diffuse Midline Glioma, H3K27M-mutant (DMG) is a rare, highly aggressive pediatric tumor affecting the brainstem, and is one of the deadliest cancers. Currently available treatment options such as chemotherapy and radiotherapy do only modestly prolong survival. In this pathology, H3K27 mutations deregulate Polycomb Repressive Complex 2 (PRC2), including enzymatic activity of EZH2, which is therefore under investigation as a therapeutic target.<h4>Methods</h4>We used a chemical ...[more]