Ontology highlight
ABSTRACT:
INSTRUMENT(S): ultraflex
ORGANISM(S): Tetrahymena Thermophila Sb210
SUBMITTER: John Burke
LAB HEAD: John Burke
PROVIDER: PXD017575 | Pride | 2020-03-18
REPOSITORIES: Pride
Items per page: 1 - 5 of 39 |
Nature communications 20200311 1
Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Inactivating mutations cause rhabdomyolysis, autoinflammatory disease, and aberrant fat storage. Disease-mutations cluster within the conserved N-Lip and C-Lip regions that are separated by 500-residues in humans. To understand how the N-Lip and C-Lip combine for PAP function, we determined crystal structures of Tetrahymena thermophila Pah2 (Tt Pah2) that directly fu ...[more]