Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture, Kidney
SUBMITTER: UoC Randles
LAB HEAD: Rachel Lennon
PROVIDER: PXD017913 | Pride | 2020-03-09
REPOSITORIES: Pride
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Randles Michael J MJ Lausecker Franziska F Humphries Jonathan D JD Byron Adam A Clark Simon J SJ Miner Jeffrey H JH Zent Roy R Humphries Martin J MJ Lennon Rachel R
Matrix biology : journal of the International Society for Matrix Biology 20200306
Cells have evolved mechanisms to sense the composition of their adhesive microenvironment. Although much is known about general mechanisms employed by adhesion receptors to relay signals between the extracellular environment and the cytoskeleton, the nuances of ligand-specific signalling remain undefined. Here, we investigated how glomerular podocytes, and four other basement membrane-associated cell types, respond morphologically to different basement membrane ligands. We defined the compositio ...[more]