Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Caenorhabditis Elegans
SUBMITTER: Mark Skehel
LAB HEAD: Mario de Bono
PROVIDER: PXD018000 | Pride | 2020-05-27
REPOSITORIES: Pride
Items per page: 1 - 5 of 610 |
Nature communications 20200429 1
Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter organismal phenotypes. We combine immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexes that function downstream of IL-17 receptors in C. elegans neurons. We identify the paracaspase MALT-1 as a critical output of the pathway. MALT1 mediates signaling from many immune ...[more]