Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Candida Albicans (yeast)
TISSUE(S): Cell Culture
SUBMITTER: David Stead
LAB HEAD: Professor Alistair J P Brown
PROVIDER: PXD018027 | Pride | 2020-06-15
REPOSITORIES: Pride
Childers Delma S DS Avelar Gabriela Mol GM Bain Judith M JM Pradhan Arnab A Larcombe Daniel E DE Netea Mihai G MG Erwig Lars P LP Gow Neil A R NAR Brown Alistair J P AJP
mBio 20200707 4
The cell wall provides a major physical interface between fungal pathogens and their mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival. Fungus-specific cell wall moieties, such as β-1,3-glucan, are recognized as pathogen-associated molecular patterns (PAMPs) that activate immune-mediated clearance mechanisms. We have reported that the opportunistic human fungal pathogen <i>Candida albicans</i> masks β-1,3-glucan following exposure to lactate, hypoxia, ...[more]