Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Candida Albicans (yeast)
TISSUE(S): Cell Culture
SUBMITTER: David Stead
LAB HEAD: Professor Alistair J P Brown
PROVIDER: PXD018027 | Pride | 2020-06-15
REPOSITORIES: pride
Action | DRS | |||
---|---|---|---|---|
CGD_SC5314_A22_20151122.fasta | Fasta | |||
WT_GluLac_Cell_Wall_1.msf | Msf | |||
WT_GluLac_Cell_Wall_1.pep.xml | Pepxml | |||
WT_GluLac_Cell_Wall_1.raw | Raw | |||
WT_GluLac_Cell_Wall_2.msf | Msf |
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Childers Delma S DS Avelar Gabriela Mol GM Bain Judith M JM Pradhan Arnab A Larcombe Daniel E DE Netea Mihai G MG Erwig Lars P LP Gow Neil A R NAR Brown Alistair J P AJP
mBio 20200707 4
The cell wall provides a major physical interface between fungal pathogens and their mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival. Fungus-specific cell wall moieties, such as β-1,3-glucan, are recognized as pathogen-associated molecular patterns (PAMPs) that activate immune-mediated clearance mechanisms. We have reported that the opportunistic human fungal pathogen <i>Candida albicans</i> masks β-1,3-glucan following exposure to lactate, hypoxia, ...[more]