Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Lung Neuroendocrine Cell, Lung
DISEASE(S): Pulmonary Neuroendocrine Tumor
SUBMITTER: John Gordan
LAB HEAD: John Gordan
PROVIDER: PXD018209 | Pride | 2020-06-17
REPOSITORIES: Pride
Action | DRS | |||
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5b1_PKA_phosphopeptides_051717.xlsx | Xlsx | |||
H29_PKA_phosphopeptides_051717.xlsx | Xlsx | |||
H82_PKA_phosphopeptides_062617.xlsx | Xlsx | |||
LX102_PKA_phosphopeptides_051717.xlsx | Xlsx | |||
PhosphoSTYSites.txt | Txt |
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Cancer cell 20200611 1
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppresses SCLC expansion in culture and in vivo. Conversely, GNAS (G-protein α subunit), a PKA activator that is genetically activated in a small subset of human SCLC, promotes SCLC development. Phosphoproteomic analyses identified many PKA substrates and mechanisms of actio ...[more]