Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell Of Cervix
SUBMITTER: Ignasi Forne
LAB HEAD: Prof. Anja Groth
PROVIDER: PXD018220 | Pride | 2021-01-18
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 16 |
Nakamura Kyosuke K Kustatscher Georg G Alabert Constance C Hödl Martina M Forne Ignasi I Völker-Albert Moritz M Satpathy Shankha S Beyer Tracey E TE Mailand Niels N Choudhary Chunaram C Imhof Axel A Rappsilber Juri J Groth Anja A
Molecular cell 20210114 5
Cells have evolved an elaborate DNA repair network to ensure complete and accurate DNA replication. Defects in these repair machineries can fuel genome instability and drive carcinogenesis while creating vulnerabilities that may be exploited in therapy. Here, we use nascent chromatin capture (NCC) proteomics to characterize the repair of replication-associated DNA double-strand breaks (DSBs) triggered by topoisomerase 1 (TOP1) inhibitors. We reveal profound changes in the fork proteome, includin ...[more]