Dataset Information

Crosslinking-MS dataset of the TFIIIC subcomplex tauA with Brf1 and TBP

ABSTRACT: Identification of crosslinks between the subunits tau131, tau95, tau55, Brf1 and TBP

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Matthias Vorländer

LAB HEAD: Christoph W Mueller

PROVIDER: PXD018232 | Pride | 2020-12-04

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	191202_P1148_Sample1_TA_interprotein_crosslinks_target.xls	Xls
	191202_P1148_Sample1_TA_intraprotein_crosslinks_target.xls	Xls
	191202_P1148_Sample1_TA_monolinks_target.xls	Xls
	AA_sequences_TauA_BTBdN.txt	Txt
	Lara_191125_P1148_MR_MV_XLINK_DSS_TA_fr1_R1.raw	Raw

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Publications

Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation.

Vorländer Matthias K MK Jungblut Anna A Karius Kai K Baudin Florence F Grötsch Helga H Kosinski Jan J Müller Christoph W CW

Nature communications 20200930 1

Transcription factor (TF) IIIC is a conserved eukaryotic six-subunit protein complex with dual function. It serves as a general TF for most RNA polymerase (Pol) III genes by recruiting TFIIIB, but it is also involved in chromatin organization and regulation of Pol II genes through interaction with CTCF and condensin II. Here, we report the structure of the S. cerevisiae TFIIIC subcomplex τA, which contains the most conserved subunits of TFIIIC and is responsible for recruitment of TFIIIB and tra ...[more]

PMID: 32999288

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