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Proteomics analysis in DIA mode of 24 weeks from the sorafenib treated and vehicle treated monkeys

ABSTRACT: Quantitative proteomics in DIA mode was used to analysis the proteomic profile of 24 weeks from the sorafenib treated and vehicle treated monkeys.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Macaca Fascicularis Fascicularis

TISSUE(S): Liver

DISEASE(S): Non-alcoholic Steatohepatitis

SUBMITTER: Xu Cheng

LAB HEAD: Hongliang Li

PROVIDER: PXD018256 | Pride | 2022-08-30

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Macacafascicularis_peptiede_Report.xls	Xls
	Macacafascicularis_protein_Report.xls	Xls
	P201901748_101-12-7_Veh.raw	Raw
	P201901748_101-15-7_Veh.raw	Raw
	P201901748_101-18-7_Veh.raw	Raw

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Publications

Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis.

Jian Chongshu C Fu Jiajun J Cheng Xu X Shen Li-Jun LJ Ji Yan-Xiao YX Wang Xiaoming X Pan Shan S Tian Han H Tian Song S Liao Rufang R Song Kehan K Wang Hai-Ping HP Zhang Xin X Wang Yibin Y Huang Zan Z She Zhi-Gang ZG Zhang Xiao-Jing XJ Zhu Lihua L Li Hongliang H

Cell metabolism 20200501 5

Nonalcoholic steatohepatitis (NASH) is becoming one of the leading causes of hepatocellular carcinoma (HCC). Sorafenib is the only first-line therapy for advanced HCC despite its serious adverse effects. Here, we report that at an equivalent of approximately one-tenth the clinical dose for HCC, sorafenib treatment effectively prevents the progression of NASH in both mice and monkeys without any observed significant adverse events. Mechanistically, sorafenib's benefit in NASH is independent of it ...[more]

PMID: 32375062

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