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Characterization of proteome dynamics in individual vascular layers at the early stage of acute sepsis

ABSTRACT: In this study we developed a stable isotope labeled of mammals (SILAM) model coupled to the application of differential systemic decellularization in vivo (DISDIVO) to evaluate the molecular dynamics of whole organism vascular beds at the initial phase of acute sepsis. Three different vascular layers where characterized at the initial stage of sepsis, glycocalyx (GC), endothelial cells (ECs) and smooth muscle cells (SMCs).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cardiovascular System

DISEASE(S): Bacterial Sepsis

SUBMITTER: Aida Serra

LAB HEAD: Aida Serra

PROVIDER: PXD018274 | Pride | 2020-10-29

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	142_PBS_LPS_SILAC2_Processed_proteins_peptides.csv	Csv
	146__PBS_LPS_SILAC3_processed_protein_peptide.xlsx	Xlsx
	150_0_5_LPS_SILAC1_processed_protein_peptide.xlsx	Xlsx
	154_0_5_LPS_SILAC2_protein_peptides_processed.xlsx	Xlsx
	158_158_PBS_LPS_SILAC1_processed_proteins_peptides.xlsx	Xlsx

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