Proteomics

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Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes


ABSTRACT: Eukaryotic flagella are complex microtubule based organelles and in many organisms there are extra-axonemal structures present, including the outer dense fibres of mammalian sperm and the paraflagellar rod (PFR) of trypanosomes. We have discovered two cytoplasmic proteins in T. brucei that are required for PFR formation, PFR assembly factors 1 and 2 and specifically interact.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Trypanosoma Brucei

SUBMITTER: Jack Sunter  

LAB HEAD: Jack Daniel Sunter

PROVIDER: PXD018331 | Pride | 2020-05-20

REPOSITORIES: Pride

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Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes.

Alves Aline A AA   Gabriel Heloisa B HB   Bezerra Maria J R MJR   de Souza Wanderley W   Vaughan Sue S   Cunha-E-Silva Narcisa L NL   Sunter Jack D JD  

Journal of cell science 20200527 10


Eukaryotic flagella are complex microtubule-based organelles that, in many organisms, contain extra-axonemal structures, such as the outer dense fibres of mammalian sperm and the paraflagellar rod (PFR) of trypanosomes. Flagellum assembly is a complex process occurring across three main compartments, the cytoplasm, the transition zone and the flagellum itself. The process begins with the translation of protein components followed by their sorting and trafficking into the flagellum, transport to  ...[more]

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