Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse, Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
SUBMITTER: Joan Josep Bech-Serra
LAB HEAD: Alex Vaquero
PROVIDER: PXD018344 | Pride | 2021-04-19
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
ADPribosylpeptides.xlsx | Xlsx | |||
SIRT6_WT_S56A_2020MB000_JUMO_001_02_5pto.raw | Raw | |||
SIRT6_WT_S56A_2020MB000_JUMO_002_02_5pto.raw | Raw | |||
SIRT6_WT_S56A_peptide.csv | Csv | |||
SIRT6_WT_S56A_proteins.csv | Csv |
Items per page: 5 1 - 5 of 18 |
Simonet Nicolás G NG Thackray Joshua K JK Vazquez Berta N BN Ianni Alessandro A Espinosa-Alcantud Maria M Morales-Sanfrutos Julia J Hurtado-Bagès Sarah S Sabidó Eduard E Buschbeck Marcus M Tischfield Jay J De La Torre Carolina C Esteller Manel M Braun Thomas T Olivella Mireia M Serrano Lourdes L Vaquero Alejandro A
Science advances 20200724 30
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity. We report that the deacetylase SirT7 is a dual sirtuin, as it also features auto-mADPRT activity. SirT7 mADPRT occurs at a previously undefined active site, and its abrogation alters SirT7 chromatin distribution. We identify an epigenetic pathway by which ADP-ribosyl-SirT7 is recognized ...[more]