Proteomics

Dataset Information

0

MRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1


ABSTRACT: The interactome of Influenza (A/WSN/33) NS1 protein (WT and D92Y mutant) was identifiedy by AP-MS.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Epithelial Cell

DISEASE(S): Influenza

SUBMITTER: Yushen Du  

LAB HEAD: Ren Sun

PROVIDER: PXD018377 | Pride | 2021-09-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
NS1wsnPointMutantPPIResults.dat Other
WSNNS1Data.zip Other
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Publications


A comprehensive examination of protein-protein interactions (PPIs) is fundamental for the understanding of cellular machineries. However, limitations in current methodologies often prevent the detection of PPIs with low abundance proteins. To overcome this challenge, we develop a mRNA display with library of even-distribution (md-LED) method that facilitates the detection of low abundance binders with high specificity and sensitivity. As a proof-of-principle, we apply md-LED to IAV NS1 protein.  ...[more]

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