Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Nothobranchius Furzeri Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Joanna Kirkpatrick
LAB HEAD: Alessandro Ori
PROVIDER: PXD018399 | Pride | 2020-08-17
REPOSITORIES: Pride
Molecular systems biology 20200601 6
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short-lived vertebrate Nothobranchius furzeri combining transcriptomics and proteomics. We detected a progressive reduction in the correlation between protein and mRNA, mainly due to post-transcriptional mechanisms that account for over 40% of the age-regulated proteins. These changes cause ...[more]