Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Endocrine Pancreas
SUBMITTER: Dina Mostafa
LAB HEAD: Tadashi Yamamoto
PROVIDER: PXD018403 | Pride | 2020-08-31
REPOSITORIES: pride
Items per page: 5 1 - 5 of 7 |
Mostafa Dina D Yanagiya Akiko A Georgiadou Eleni E Wu Yibo Y Stylianides Theodoros T Rutter Guy A GA Suzuki Toru T Yamamoto Tadashi T
Communications biology 20200828 1
Pancreatic β-cells are responsible for production and secretion of insulin in response to increasing blood glucose levels. Defects in β-cell function lead to hyperglycemia and diabetes mellitus. Here, we show that CNOT3, a CCR4-NOT deadenylase complex subunit, is dysregulated in islets in diabetic db/db mice, and that it is essential for murine β cell maturation and identity. Mice with β cell-specific Cnot3 deletion (Cnot3βKO) exhibit impaired glucose tolerance, decreased β cell mass, and they g ...[more]