Dataset Information

Effect of integrin α3β1 and/or integrin α9β1 expression on the mouse keratinocyte secretome

ABSTRACT: A parental immortalized mouse keratinocyte cell line which lacks integrin α3β1 and α9β1 were engineered to express either α3β1, α9β1, or α3β1 and α9β1 in combination. The conditioned medium from these cell lines were analyzed by MS/MS.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Keratinocyte

SUBMITTER: Scott Varney

LAB HEAD: Mike DiPersio

PROVIDER: PXD018425 | Pride | 2022-02-15

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	4448_tc_o292_F1A_f08260.mzid	Mzid
	4449_tc_o292_F2A_f08261.mzid	Mzid
	4450_tc_o292_F3A_f08262.mzid	Mzid
	4451_tc_o292_F4A_f08263.mzid	Mzid
	4452_tc_o292_F5A_f08264.mzid	Mzid

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Publications

Integrin α3β1 on Tumor Keratinocytes Is Essential to Maintain Tumor Growth and Promotes a Tumor-Supportive Keratinocyte Secretome.

Longmate Whitney M WM Varney Scott S Power Derek D Miskin Rakshitha Pandulal RP Anderson Karl E KE DeFreest Lori L Van De Water Livingston L DiPersio C Michael CM

The Journal of investigative dermatology 20200523 1

The development of integrin-targeted cancer therapies is hindered by incomplete understanding of integrin function in tumor cells and the tumor microenvironment. Previous studies showed that mice with epidermis-specific deletion of the α3 integrin subunit fail to form skin tumors during two-step chemical tumorigenesis, indicating a protumorigenic role for integrin α3β1. Here, we generated mice with tamoxifen-inducible, epidermis-specific α3 knockout to determine the role of α3β1 in the maintenan ...[more]

PMID: 32454065

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