Dataset Information
Par3A and Par3B interactome IMCDs
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: 
Martin Hoehne
LAB HEAD: Paul Thomas Brinkkoetter
PROVIDER: PXD018637 | Pride | 2022-07-07
REPOSITORIES: Pride
Dataset's files
Items per page: 1 - 5 of 19 |
Publications
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.
Kidney international 20211217 4
Glomerular diseases are a major cause for chronic kidney disorders. In most cases podocyte injury is causative for disease development. Cytoskeletal rearrangements and morphological changes are hallmark features of podocyte injury and result in dedifferentiation and loss of podocytes. Here, we establish a link between the Par3 polarity complex and actin regulators necessary to establish and maintain podocyte architecture by utilizing mouse and Drosophila models to characterize the functional rol ...[more]
