Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Bogdan Florea
LAB HEAD: Bogdan Iulius Florea
PROVIDER: PXD018661 | Pride | 2020-04-29
REPOSITORIES: Pride
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20191125_JV_DMSO_01.zip.raw | Raw | |||
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20191125_JV_DMSO_03.zip.raw | Raw | |||
20191125_JV_DMSO_04.zip.raw | Raw | |||
20191125_JV_OLPRB-003_01.zip.raw | Raw |
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Chembiochem : a European journal of chemical biology 20200513 17
The poly-ADP-ribose polymerase (PARP) is a protein from the family of ADP-ribosyltransferases that catalyzes polyadenosine diphosphate ribose (ADPR) formation in order to attract the DNA repair machinery to sites of DNA damage. The inhibition of PARP activity by olaparib can cause cell death, which is of clinical relevance in some tumor types. This demonstrates that quantification of PARP activity in the context of living cells is of great importance. In this work, we present the design, synthes ...[more]