MS analysis of SARS-CoV2 proteins from patient samples
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ABSTRACT: We developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. Our protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our methodology identifies unique peptides originating from SARS-CoV-2 nucleoprotein. Building on these promising initial results, faster MS protocols can now be developed as routine diagnostic tools for COVID-19 patients. https://biorxiv.org/cgi/content/short/2020.04.18.047878v1
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Saliva
DISEASE(S): Severe Acute Respiratory Syndrome
SUBMITTER: Christian Ihling
LAB HEAD: Andrea Sinz
PROVIDER: PXD018682 | Pride | 2020-04-24
REPOSITORIES: Pride
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