Proteomics

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Proteomic Investigations of Two Pakistani Naja Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications and Presence of Extracellular Vesicles

ABSTRACT: Latest advancement of omics technologies allows in-depth characterization of venom compositions. In the present work we present a proteomic study of two snake venoms of the genus Naja i.e. Naja naja (black cobra) and Naja oxiana (brown cobra), of Pakistani origin. The present study has shown that these snake venoms consist of a highly diversified proteome. Furthermore, the data also revealed variation among closely related species. High throughput mass spectrometric analysis of the venom proteome allowed to identify for the N. naja venom 34 protein families and for the N. oxiana 24 protein families. The comparative evaluation of the two venoms showed that N. naja consists of a more complex venom proteome than N. oxiana venom.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Naja Oxiana Naja Naja

TISSUE(S): Venom

SUBMITTER: Benjamin Dreyer  

LAB HEAD: Hartmut Schlüter

PROVIDER: PXD018726 | Pride | 2020-10-29

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
180918_King_cobra_18387_entries.fasta Fasta
180918_Venom_Naja_naja.raw Raw
180918_Venom_Naja_naja_against_King_Cobra_database.mzML Mzml
180918_Venom_Naja_naja_against_King_Cobra_database.mzid.gz Mzid
180918_Venom_Naja_naja_against_King_Cobra_database.pride.mgf.gz Mgf
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Proteomic Investigations of Two Pakistani <i>Naja</i> Snake Venoms Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles.

Manuwar Aisha A   Dreyer Benjamin B   Böhmert Andreas A   Ullah Anwar A   Mughal Zia Z   Akrem Ahmed A   Ali Syed Abid SA   Schlüter Hartmut H   Betzel Christian C  

Toxins 20201022 11

Latest advancement of omics technologies allows in-depth characterization of venom compositions. In the present work we present a proteomic study of two snake venoms of the genus <i>Naja</i> i.e., <i>Naja naja</i> (black cobra) and <i>Naja oxiana</i> (brown cobra) of Pakistani origin. The present study has shown that these snake venoms consist of a highly diversified proteome. Furthermore, the data also revealed variation among closely related species. High throughput mass spectrometric analysis  ...[more]

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