Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Squamous Cell Of Epidermis
DISEASE(S): Skin Cancer
SUBMITTER: Alex von kriegsheim
LAB HEAD: Alex von kriegsheim
PROVIDER: PXD018745 | Pride | 2021-09-09
REPOSITORIES: pride
Action | DRS | |||
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02_SCC-FAK-WT-Ambra1-1_170515102008.raw | Raw | |||
03_SCC-FAK-WT-Ambra1-2.raw | Raw | |||
04_SCC-FAK-WT-Ambra1-3.raw | Raw | |||
06_SCC-FAK-WT-IgG-1.raw | Raw | |||
07_SCC-FAK-WT-IgG-2.raw | Raw |
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The Journal of biological chemistry 20200702 34
Ambra1 is considered an autophagy and trafficking protein with roles in neurogenesis and cancer cell invasion. Here, we report that Ambra1 also localizes to the nucleus of cancer cells, where it has a novel nuclear scaffolding function that controls gene expression. Using biochemical fractionation and proteomics, we found that Ambra1 binds to multiple classes of proteins in the nucleus, including nuclear pore proteins, adaptor proteins such as FAK and Akap8, chromatin-modifying proteins, and tra ...[more]