Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Stem Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: severine chambeyron
LAB HEAD: CHAMBEYRON SEVERINE
PROVIDER: PXD018749 | Pride | 2020-07-21
REPOSITORIES: Pride
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Nature communications 20200604 1
In eukaryotes, trimethylation of lysine 9 on histone H3 (H3K9) is associated with transcriptional silencing of transposable elements (TEs). In drosophila ovaries, this heterochromatic repressive mark is thought to be deposited by SetDB1 on TE genomic loci after the initial recognition of nascent transcripts by PIWI-interacting RNAs (piRNAs) loaded on the Piwi protein. Here, we show that the nucleosome remodeler Mi-2, in complex with its partner MEP-1, forms a subunit that is transiently associat ...[more]