Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Vaccinia Virus
SUBMITTER: Dorothea Anrather
LAB HEAD: Tim Skern
PROVIDER: PXD018786 | Pride | 2020-10-02
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 16 |
Azar Daniel F DF Haas Meryl M Fedosyuk Sofiya S Rahaman Md Habibur MH Hedger Andrew A Kobe Bostjan B Skern Tim T
Structure (London, England : 1993) 20201008 12
Vaccinia virus A46 is an anti-inflammatory and non-anti-apoptotic, two-domain member of the poxviral Bcl-2-like protein family that inhibits the cellular innate immune response at the level of the Toll/interleukin-1 receptor (TIR) domain-containing TLR adaptor proteins MAL, MyD88, TRAM, and TRIF. The mechanism of interaction of A46 with its targets has remained unclear. The TIR domains of MAL and MyD88 have been shown to signal by forming filamentous assemblies. We show a clear concentration-dep ...[more]