Dataset Information

DIA analysis of colorectal cancer organoids

ABSTRACT: The goal of this project was to characterize the proteome and phosphoproteome of colorectal cancer organoids.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Peter Blattmann

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD018913 | Pride | 2023-12-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20200427_223145_PB_200405_CRC_P_Report.xls	Xls
	20200428_000713_PB_200419_CRC_TL_Report.xls	Xls
	DIA_windows.txt	Txt
	PB_200425_CRC_P_ConditionSetup.xls	Xls
	PB_200426_CRC_TL_ConditionSetup.xls	Xls

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Publications

Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer.

Plattner Christina C Lamberti Giorgia G Blattmann Peter P Kirchmair Alexander A Rieder Dietmar D Loncova Zuzana Z Sturm Gregor G Scheidl Stefan S Ijsselsteijn Marieke M Fotakis Georgios G Noureen Asma A Lisandrelli Rebecca R Böck Nina N Nemati Niloofar N Krogsdam Anne A Daum Sophia S Finotello Francesca F Somarakis Antonios A Schäfer Alexander A Wilflingseder Doris D Gonzalez Acera Miguel M Öfner Dietmar D Huber Lukas A LA Clevers Hans H Becker Christoph C Farin Henner F HF Greten Florian R FR Aebersold Ruedi R de Miranda Noel F C C NFCC Trajanoski Zlatko Z

iScience 20231104 12

Precision oncology approaches for patients with colorectal cancer (CRC) continue to lag behind other solid cancers. Functional precision oncology-a strategy that is based on perturbing primary tumor cells from cancer patients-could provide a road forward to personalize treatment. We extend this paradigm to measuring proteome activity landscapes by acquiring quantitative phosphoproteomic data from patient-derived organoids (PDOs). We show that kinase inhibitors induce inhibitor- and patient-speci ...[more]

PMID: 38047086

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