Dataset Information
Novel Aza-Podophyllotoxin Derivative in Triple Negative Breast Cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: 
Sharon Pitteri
LAB HEAD: Sharon Pitteri
PROVIDER: PXD018929 | Pride | 2020-11-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 10ANSC212_kegg.GseaPreranked.1556929753204.zip | Other | |||
| 10ANSC_1.raw | Raw | |||
| 10ANSC_2.raw | Raw | |||
| 10ANSC_3.raw | Raw | |||
| 10ANSCtxt.zip | Other |
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Publications
Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer.
British journal of cancer 20201103 3
<h4>Background</h4>To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these metabolic interventions work via indirectly activating AMP-activated protein kinase (AMPK) to alter cellular metabolism in favour of oxidative phosphorylation over aerobic glycolysis. The effect of these drugs is dependent on glycaemic and insulin conditions. Ther ...[more]
