Effect of HDAC inhibitors on acetylated histones in P. pacificus
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Pristionchus Pacificus
TISSUE(S): Whole Body
SUBMITTER: 
Nicolas Nalpas
LAB HEAD: Ralf J. Sommer
PROVIDER: PXD018940 | Pride | 2023-02-24
REPOSITORIES: Pride
Dataset's files
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| 20190822_CO_0856RaSo_R06_1.raw | Raw | |||
| 20190822_CO_0856RaSo_R06_2.raw | Raw | |||
| 20190822_CO_0856RaSo_R06_3.raw | Raw | |||
| 20190822_CO_0856RaSo_R07_1.raw | Raw | |||
| 20190822_CO_0856RaSo_R07_2.raw | Raw |
Items per page: 5 1 - 5 of 19 |
Publications
Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.
Werner Michael S MS Loschko Tobias T King Thomas T Reich Shelley S Theska Tobias T Franz-Wachtel Mirita M Macek Boris B Sommer Ralf J RJ
Nature communications 20230413 1
Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown. Here, we show that plasticity of nematode mouth forms is determined by histone 4 lysine 5 and 12 acetylation (H4K5/12ac). Acetylation in early larval stages provides a permissive chromatin state, which i ...[more]
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