Dataset Information

Discovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohns patients: a proteomics-based study

ABSTRACT: Objective: A subset of Crohns disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients.Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined therapy (antimetabolite and infliximab) and stable clinical remission (STORI cohort, n=102). From shotgun proteomics experiment (discovery step), biomarker candidates were identified and further targeted by selected reaction monitoring (verification step). The dataset was stratified to search for markers of short- (<6 months) or long-term relapse (>6 months). The risk of relapse and the predicting capacity associated with biomarker candidates were evaluated using univariate Cox model and log-rank statistic, respectively. To test their complementary predicting capacity, biomarker candidates were systematically combined in pairs. Results: Distinct biomarker candidates were associated with the risk (hazard ratio: HR) of short- (15 proteins, 2.9

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Crohn's Disease

SUBMITTER: nicolas Pierre

LAB HEAD: Edouard LOUIS

PROVIDER: PXD019008 | Pride | 2020-10-19

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	121130-24743-09-AII-F01_IA_final_protein.csv	Csv
	121130-24750-09-AII-F01_IA_final_protein.csv	Csv
	121130-24752-09-AII-F01_IA_final_protein.csv	Csv
	121203-24741-09-AII-F01_IA_final_protein.csv	Csv
	121203-24745-09-AII-F01_IA_final_protein.csv	Csv

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Discovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohns patients: a proteomics-based study

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