5224 Payne May 2020 Data Characterize proteins binding to nanoparticle surfaces
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Bos Taurus (bovine)
TISSUE(S): Blood Plasma
SUBMITTER: 
Erik Soderblom
LAB HEAD: Erik Soderblom
PROVIDER: PXD019118 | Pride | 2020-06-10
REPOSITORIES: pride
Dataset's files
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Publications
Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data.
Poulsen Karsten M KM Pho Thomas T Champion Julie A JA Payne Christine K CK
Analytical and bioanalytical chemistry 20200604 24
Nanoparticles used in biological settings are exposed to proteins that adsorb on the surface forming a protein corona. These adsorbed proteins dictate the subsequent cellular response. A major challenge has been predicting what proteins will adsorb on a given nanoparticle surface. Instead, each new nanoparticle and nanoparticle modification must be tested experimentally to determine what proteins adsorb on the surface. We propose that any future predictive ability will depend on large datasets o ...[more]
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