Dataset Information

SARS-CoV-2 induced glycolysis is essential for monocytes inflammatory response

ABSTRACT: We have analyzed through shotgun proteomics approach Macrophages and Monocytes infected by the virus Sars-Cov 2, performing a qualitative and quantitative analysis.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Monocyte, Cell Culture, Macrophage

DISEASE(S): Covid-19

SUBMITTER: Victor Corasolla Carregari

LAB HEAD: Daniel Martins-de-Souza

PROVIDER: PXD019157 | Pride | 2021-09-09

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	D.zip	Other
	Sars-Cov2_Project.DerivedFromSearch59355e98-acc2-42ec-8e00-2d699317a9c5.mgf	Mgf
	Sars-Cov2_Project.DerivedFromSearch59355e98-acc2-42ec-8e00-2d699317a9c5.pride.mgf.gz	Mgf
	Sars-Cov2_Project.mzid.gz	Mzid
	Sars-Cov2_Project.pride.mztab.gz	Mztab

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Publications

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.

Codo Ana Campos AC Davanzo Gustavo Gastão GG Monteiro Lauar de Brito LB de Souza Gabriela Fabiano GF Muraro Stéfanie Primon SP Virgilio-da-Silva João Victor JV Prodonoff Juliana Silveira JS Carregari Victor Corasolla VC de Biagi Junior Carlos Alberto Oliveira CAO Crunfli Fernanda F Jimenez Restrepo Jeffersson Leandro JL Vendramini Pedro Henrique PH Reis-de-Oliveira Guilherme G Bispo Dos Santos Karina K Toledo-Teixeira Daniel A DA Parise Pierina Lorencini PL Martini Matheus Cavalheiro MC Marques Rafael Elias RE Carmo Helison R HR Borin Alexandre A Coimbra Laís Durço LD Boldrini Vinícius O VO Brunetti Natalia S NS Vieira Andre S AS Mansour Eli E Ulaf Raisa G RG Bernardes Ana F AF Nunes Thyago A TA Ribeiro Luciana C LC Palma Andre C AC Agrela Marcus V MV Moretti Maria Luiza ML Sposito Andrei C AC Pereira Fabrício Bíscaro FB Velloso Licio Augusto LA Vinolo Marco Aurélio Ramirez MAR Damasio André A Proença-Módena José Luiz JL Carvalho Robson Francisco RF Mori Marcelo A MA Martins-de-Souza Daniel D Nakaya Helder I HI Farias Alessandro S AS Moraes-Vieira Pedro M PM

Cell metabolism 20200717 3

COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of th ...[more]

PMID: 32697943

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