Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Francis O'Reilly
LAB HEAD: Juri Rappsilber
PROVIDER: PXD019275 | Pride | 2020-07-28
REPOSITORIES: Pride
Lee Byung-Gil BG Merkel Fabian F Allegretti Matteo M Hassler Markus M Cawood Christopher C Lecomte Léa L O'Reilly Francis J FJ Sinn Ludwig R LR Gutierrez-Escribano Pilar P Kschonsak Marc M Bravo Sol S Nakane Takanori T Rappsilber Juri J Aragon Luis L Beck Martin M Löwe Jan J Haering Christian H CH
Nature structural & molecular biology 20200713 8
Complexes containing a pair of structural maintenance of chromosomes (SMC) family proteins are fundamental for the three-dimensional (3D) organization of genomes in all domains of life. The eukaryotic SMC complexes cohesin and condensin are thought to fold interphase and mitotic chromosomes, respectively, into large loop domains, although the underlying molecular mechanisms have remained unknown. We used cryo-EM to investigate the nucleotide-driven reaction cycle of condensin from the budding ye ...[more]