Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Alveolar Macrophage
SUBMITTER: Hye-Young Kim
LAB HEAD: Ilona, Jaspers
PROVIDER: PXD019317 | Pride | 2020-07-18
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 240 |
Duffney Parker F PF Kim Hye-Young H HH Porter Ned A NA Jaspers Ilona I
The Journal of biological chemistry 20200720 36
Inhalation of the ambient air pollutant ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B (SecoA and SecoB), which can form covalent adducts on cellular proteins. How oxysterol-protein adduction modifies the function of lung macrophages is unknown. Herein, we used a proteomic screen to identify lung macrophage proteins that form addu ...[more]