Dataset Information

BioID2-Synapsin proteome Soderling

ABSTRACT: To determine the proteome of presynaptic terminals based on a BioID2-synapsin probe.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Erik Soderblom

LAB HEAD: Erik Soderblom

PROVIDER: PXD019342 | Pride | 2021-07-15

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	ID37387_01_FSN20357_4991_033018.mgf	Mgf
	ID37387_01_FSN20357_4991_033018.raw	Raw
	ID37388_01_FSN20357_4991_033018.mgf	Mgf
	ID37388_01_FSN20357_4991_033018.raw	Raw
	ID37389_01_FSN20357_4991_033018.mgf	Mgf

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Publications

Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.

Courtland Jamie L JL Bradshaw Tyler Wa TW Waitt Greg G Soderblom Erik J EJ Ho Tricia T Rajab Anna A Vancini Ricardo R Kim Il Hwan IH Soderling Scott H SH

eLife 20210322

Mutation of the Wiskott-Aldrich syndrome protein and SCAR homology (WASH) complex subunit, SWIP, is implicated in human intellectual disability, but the cellular etiology of this association is unknown. We identify the neuronal WASH complex proteome, revealing a network of endosomal proteins. To uncover how dysfunction of endosomal SWIP leads to disease, we generate a mouse model of the human WASHC4c.3056C>G mutation. Quantitative spatial proteomics analysis of SWIPP1019R< ...[more]

PMID: 33749590

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