Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Myeloid Cell, Blood
DISEASE(S): Myeloid Leukemia
SUBMITTER: Sara Zanivan
LAB HEAD: Sara Zanivan
PROVIDER: PXD019347 | Pride | 2020-09-28
REPOSITORIES: Pride
Items per page: 1 - 5 of 38 |
Cancer & metabolism 20200921
<h4>Background</h4>Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it is not clear how formate induces pyrimidine synthesis.<h4>Methods</h4>Here we combine phospho-proteome and metabolic profiling to determine how formate induces pyrimidine synthesis.<h4>Results</h4>We discover that formate induces phosphorylation of carbamoyl phosphate sy ...[more]