Proteomics

Dataset Information

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Proteomic analysis of cerebellar synaptosomes in presymptomatic cystatin B –deficient mice


ABSTRACT: Loss-of-function mutations in cystatin B (CSTB) cause progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1). Cstb-deficiency in mice leads to early alterations in GABAergic signaling, and causes neuroinflammation followed by progressive neurodegeneration, manifesting as progressive myoclonus and ataxia. The proteome of cerebellar synaptosomes of presymptomatic Cstb-/- mice were characterized by LC-ESI-MS/MS to gain insight into disease formation and progression.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Tuula Nyman  

LAB HEAD: Tuula Nyman

PROVIDER: PXD019370 | Pride | 2020-10-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
160331_KO14.raw Raw
160331_KO18.raw Raw
160331_KO20.raw Raw
160331_KO21.raw Raw
160331_KO22.raw Raw
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