Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Rahul Kanadia
LAB HEAD: Rahul Kanadia
PROVIDER: PXD019428 | Pride | 2021-09-09
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 28 |
Olthof Anouk M AM White Alisa K AK Mieruszynski Stephen S Doggett Karen K Lee Madisen F MF Chakroun Almahdi A Abdel Aleem Alice K AK Rousseau Justine J Magnani Cinzia C Roifman Chaim M CM Campeau Philippe M PM Heath Joan K JK Kanadia Rahul N RN
Nucleic acids research 20210401 6
Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by the major and minor spliceosomes, respectively. Major intron splicing follows the exon-definition model, whereby major spliceosome components first assemble across exons. However, since most genes with minor introns predominately consist of major introns, formation of exon-definition complexes in these genes would require interaction between the major and minor spliceosomes. Here, we report that minor spliceo ...[more]