Dataset Information

Circadian Mouse Articular Cartilage Proteomics

ABSTRACT: Mouse hip articular cartilage was collected every 4 hour for 48 hours and analysed by mass spec

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Articular Cartilage

SUBMITTER: Michal Dudek

LAB HEAD: Qing-Jun Meng

PROVIDER: PXD019431 | Pride | 2021-03-01

REPOSITORIES: Pride

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Publications

Circadian time series proteomics reveals daily dynamics in cartilage physiology.

Dudek M M Angelucci C C Pathiranage D D Wang P P Mallikarjun V V Lawless C C Swift J J Kadler K E KE Boot-Handford R P RP Hoyland J A JA Lamande S R SR Bateman J F JF Meng Q-J QJ

Osteoarthritis and cartilage 20210219 5

<h4>Objective</h4>Cartilage in joints such as the hip and knee experiences repeated phases of heavy loading and low load recovery during the 24-h day/night cycle. Our previous work has shown 24 h rhythmic changes in gene expression at transcript level between night and day in wild type mouse cartilage which is lost in a circadian clock knock-out mouse model. However, it remains unknown to what extent circadian rhythms also regulate protein level gene expression in this matrix rich tissue.<h4>Met ...[more]

PMID: 33610821

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