Proteomics

Dataset Information

0

Cigarette smoke extract-treated alveolar macrophage-derived extracellular vesicles


ABSTRACT: This project is based upon the fundamental observation that alveolar macrophage-derived extracellular vesicles (AM-EVs), when internalized by neighboring epithelial cells, inhibit their infection by influenza virus. This inhibitory activity of AM-EVs is abolished when AMs are treated with cigarette smoke extract (CSE). We chose to survey the AM-EV proteome in an effort to identify candidate proteins whose abundance within EVs was downregulated by CSE treatment of AMs, thus explaining the ability of CSE to abrogate the inhibitory activity against influenza.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung, Cell Culture, Macrophage

DISEASE(S): Disease Free

SUBMITTER: Daniel Schneider  

LAB HEAD: Daniel Joseph Schneider

PROVIDER: PXD019528 | Pride | 2020-06-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
PRF_F_2019_M_PETE_81_1.raw Raw
PRF_F_2019_M_PETE_81_1_8.msf Msf
PRF_F_2019_M_PETE_81_1_8.msfView Msf
PRF_F_2019_M_PETE_81_1_8.pdResult Other
PRF_F_2019_M_PETE_81_1_8.pdResultView Other
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