Ontology highlight
ABSTRACT:
INSTRUMENT(S): quadrupole
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Qi Wang
LAB HEAD: Qi Wang
PROVIDER: PXD019638 | Pride | 2022-02-15
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
L-B2-Br0-1.qgd | Other | |||
L-B2-Br0-2.qgd | Other | |||
L-B2-Br0-3.qgd | Other | |||
L-B2-Br0-5.qgd | Other | |||
L-B2-Br0-6.qgd | Other |
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Clinical and translational medicine 20210901 9
<h4>Background</h4>Platinum-based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows finite therapeutic efficacy in patients suffering from brain metastasis (BM). The intrinsic changes of BM cells, which contribute to the poor results remain unknown.<h4>Methods</h4>Platinum drug-sensitivity was assessed by utilizing a preclinical BM model of PC9 lung adenocarcinoma cells in vitro and in vivo. High consumption of glutathione (GSH) and two associated ...[more]