Quantitative proteomic analysis of hypoxia induced primary kidney cells

ABSTRACT: Chronic kidney disease (CKD) is characterized by a slow and gradual loss of kidney function, with glomerular filtration loss over months or years, inevitably leading to end-stage renal disease. The renal failure resulting from this irreversible process derives from fibrotic lesions of each compartment of the kidney; glomerulosclerosis, vascular sclerosis, and tubulointerstitial fibrosis. Nevertheless, despite numerous research efforts, both the definitive mechanism underlying the progression from CKD to end stage renal disease and an effective treatment have remained elusive. In this study, We utilized TMT-multiplexed quantitative proteomics approaches to identify protein expression changes associated with chronic injury in primary cultured renal cells.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Glomerular Endothelial Cell, Proximal Tubular Epithelium, Kidney

DISEASE(S): Chronic Kidney Disease

SUBMITTER: Dohyun Han  

LAB HEAD: Dohyun Han

PROVIDER: PXD019678 | Pride | 2021-01-19

REPOSITORIES: Pride