Dataset Information

Proteomic analysis of SYNCRIP deficient HSPCs

ABSTRACT: Alterations in SYNCRIP activity were found to alter gene transcription in leukemia cells. The effects of transcription alterations on expression of the corresponding proteins were investigated by LC/MSMS

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Stem Cell

DISEASE(S): Acute Leukemia

SUBMITTER: Alex Kentsis

LAB HEAD: Alex Kentsis

PROVIDER: PXD019779 | Pride | 2023-05-10

REPOSITORIES: Pride

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RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.

Herrejon Chavez Florisela F Luo Hanzhi H Cifani Paolo P Pine Alli A Chu Eren L EL Joshi Suhasini S Barin Ersilia E Schurer Alexandra A Chan Mandy M Chang Kathryn K Han Grace Y Q GYQ Pierson Aspen J AJ Xiao Michael M Yang Xuejing X Kuehm Lindsey M LM Hong Yuning Y Nguyen Diu T T DTT Chiosis Gabriela G Kentsis Alex A Leslie Christina C Vu Ly P LP Kharas Michael G MG

Nature communications 20230421 1

Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. Here, using a conditional knockout mouse model, we revealed that the RNA-binding protein SYNCRIP is required for maintenance of blood homeostasis especially after regenerative stress due to defects in HSCs and progenitors. Mechanistically, we find that SYN ...[more]

PMID: 37085479

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