Proteomics

Dataset Information

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Analysis of SARS-CoV-2 S and human ACE2 protein by LC-MS


ABSTRACT: Analysis of deglycosylated N-linked glycopeptides for SARS-Cov-2 S and human ACE2 protein by LC-MS

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Severe Acute Respiratory Syndrome Coronavirus 2

TISSUE(S): Epithelial Cell

SUBMITTER: Peng Zhao  

LAB HEAD: Lance Wells

PROVIDER: PXD019938 | Pride | 2020-09-09

REPOSITORIES: Pride

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Publications


The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific microheterogeneity of glycosylation for a recombinant trimer Spike mimetic immunogen and for a soluble version of human ACE2. We combined this information with bioinformatics analyses of natural variants and with existi  ...[more]

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