Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
SUBMITTER: Kevin Klann
LAB HEAD: Christian Münch
PROVIDER: PXD019950 | Pride | 2020-11-05
REPOSITORIES: Pride
Action | DRS | |||
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20200621_KKL_CoV2_Targeted_MS2_new-1.msf | Msf | |||
20200621_KKL_CoV2_Targeted_MS2_new.raw | Raw | |||
Mass_list_02.txt | Txt |
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Bojkova Denisa D Bechtel Marco M McLaughlin Katie-May KM McGreig Jake E JE Klann Kevin K Bellinghausen Carla C Rohde Gernot G Jonigk Danny D Braubach Peter P Ciesek Sandra S Münch Christian C Wass Mark N MN Michaelis Martin M Cinatl Jindrich J
Cells 20201030 11
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S) protein by cellular proteases. Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin) inhibited SARS-CoV-2 replication in therapeutically achievable concentrations. An analysis of prote ...[more]