Proteomics

Dataset Information

0

Targeted multiplexed proteomics of SARS-CoV-2 peptides in ALI cells


ABSTRACT: Human air-liquid-interface cultured cells (ALI) were infected with SARS-CoV-2 in presence or absence of the drug aprotinin. Targeted proteomics were performed on previously identified peptides modified with TMTpro.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Kevin Klann  

LAB HEAD: Christian Münch

PROVIDER: PXD019950 | Pride | 2020-11-05

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20200621_KKL_CoV2_Targeted_MS2_new-1.msf Msf
20200621_KKL_CoV2_Targeted_MS2_new.raw Raw
Mass_list_02.txt Txt
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Publications


Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S) protein by cellular proteases. Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin) inhibited SARS-CoV-2 replication in therapeutically achievable concentrations. An analysis of prote  ...[more]

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