Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Oligodendrocyte
SUBMITTER: Olaf Jahn
LAB HEAD: PD Dr. Olaf Jahn
PROVIDER: PXD020007 | Pride | 2020-07-16
REPOSITORIES: Pride
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Frontiers in cellular neuroscience 20200819
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since. Here we revisit the proteome of myelin biochemically purified from the brains of healthy c56Bl/6N-mice utilizing complementary proteomic approaches for deep qualitative and quantitative coverage. By gel-free, label-free mass spectrometry, the most abundant myelin proteins PLP, MBP, CNP, and MOG cons ...[more]