Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Heart
SUBMITTER: Maggie Pui Yu Lam
LAB HEAD: Maggie PY Lam
PROVIDER: PXD020074 | Pride | 2022-05-19
REPOSITORIES: Pride
Items per page: 1 - 5 of 98 |
Journal of molecular and cellular cardiology 20210205
Alternative splicing is prevalent in the heart and implicated in many cardiovascular diseases, but not every alternative transcript is translated and detecting non-canonical isoforms at the protein level remains challenging. Here we show the use of a computation-assisted targeted proteomics workflow to detect protein alternative isoforms in the human heart. We build on a recent strategy to integrate deep RNA-seq and large-scale mass spectrometry data to identify candidate translated isoform pept ...[more]